C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 455/03 (2006.01)
Patent
CA 2474848
The invention provides novel tyloindicines analogues and related processes, pharmaceutical compositions, and methods. The novel tyloindicines are useful in a wide variety of antiviral, antineoplastic, antibacterial, and anti- inflammatory applications. Preferred embodiments of the instant invention include the novel tyloindicine designated herein as compound IT-3 (NSC- 716802). Compounds of the instant invention have exhibited potent antiviral and anticancer activity in vitro. The invention further provides novel methods of treating neoplastic, bacterial, viral, and anti-inflammatory disorders using tyloindicines including the novel tyloindicine analogues of the instant invention. The invention also provides novel syntheses of tyloindicines including the novel tyloindicines analogues of the instant invention.
Cette invention concerne de nouveaux analogues de tyloindicines et des composés s'y rapportant, des compositions pharmaceutiques, et des méthodes associées. Les nouveaux tyloindicines sont utiles dans un grand nombre d'applications antivirales, antinéoplastiques, antibactériennes ou anti-inflammatoires. Des modes préférés de l'invention comprennent la nouvelle tyloindicine, appelée ici composé IT-3 (NSC-716802). Les composés de l'invention ont démontré une puissante action antivirale et anticancéreuse in vitro. L'invention concerne également de nouvelles méthodes de traitement de troubles néoplastiques, bactériens, viraux ou anti-inflammatoires mettant en oeuvre les tyloindicines de l'invention, y compris de nouveaux analogues des tyloindicines. L'invention concerne en outre de nouvelles synthèses de tyloindicines comprenant les nouveaux analogues de tyloindicines de l'invention.
Baker David C.
Cheng Yung-Chi
Zhong Sanbao
Cassan Maclean
University Of Tennessee Research Foundation
Yale University
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