Methods for designing and synthesizing directed sequence...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/34 (2006.01)

Patent

CA 2649296

The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the modulation of unwanted immune responses, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use.

La présente invention concerne un procédé de synthèse en phase solide de mélanges de peptides à épitopes dirigés utiles pour moduler des réponses immunitaires indésirables, ledit procédé étant défini par un ensemble de règles concernant l'identité et la fréquence d'occurrence d'acides aminés substituant une base ou un acide aminé natif d'un épitope connu. La composition résultante est un mélange de peptides apparentés à usage thérapeutique.

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