A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/00 (2006.01)
Patent
CA 2752181
The present invention relates to a method for complexation of a chelate with a radionuclide, advantageously gallium, the complexation being carried out advantageously at ambient temperature without heating, by adding the radionuclide to the chelate in a buffer solution, the buffer of this solution comprising between two and five functions for coordination with the radionuclide, each coordination function being independently chosen from a carboxylic acid function and a hydroxyl function, on the condition that the buffer comprises at least one carboxylic acid function and at most two carboxylic acid functions. It also relates to the injectable solution obtained.
La présente invention concerne un procédé de complexation d'un chélate avec un radionucléide, de façon avantageuse le gallium, la complexation étant conduite de façon avantageuse à température ambiante sans chauffage, par ajout du radionucléide au chélate dans une solution tampon, le tampon de cette solution comprenant entre deux et cinq fonctions de coordination avec le radionucléide, chaque fonction de coordination étant indépendamment choisie parmi une fonction acide carboxylique et une fonction hydroxyle, à condition que le tampon comprenne au moins une fonction acide carboxylique et au maximum deux fonctions acides carboxyliques. L'invention concerne également la solution injectable obtenue.
Medina Christelle
Port Marc
Guerbet
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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