Lag1: a gene for increasing the longevity of eukaryotes

Details Lag1: a gene for increasing the longevity of eukaryotes Lag1: a gene for increasing the longevity of eukaryotes

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 31/70 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) C07K 14/395 (2006.01) C07K 14/47 (2006.01) C07K 16/14 (2006.01) C12N 1/19 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2191104

The present invention provides a unique eukaryotic gene, called LAG1, which controls the longevity of eukaryotic cells. According to the present invention, over expression of LAG1 in older cells has a rejuvenating effect which not only increases cellular life span but also reproductive capacity and cellular tolerance to stress factors such as starvation and low pH. Moreover, the present invention identifies two domains in LAG1 one having a life span limiting function and the other a life span extending function. Hence, according to the present invention, the longevity and tolerance to stress of cells is increased when provided with the wild type polypeptide or mutant LAG1 polypeptides which, for example, lack the "life span limiting domain".

La présente invention concerne un nouveau gène eucaryotique appelé <u>LAG1</u>, qui contrôle la longévité des cellules eucaryotiques. Selon la présente invention, la surexpression de <u>LAG1</u> dans les cellules plus âgées a un effet rajeunissant qui non seulement augmente la durée de vie des cellules, mais également leur capacité à la reproduction et leur résistance à des facteurs de stress, tels que la privation d'éléments nutritifs et un pH bas. En outre, on a identifié deux domaines dans <u>LAG1</u>, un qui a pour effet de limiter la durée de vie et l'autre d'augmenter la durée de vie. Par conséquent, on peut augmenter la longévité et la résistance aux facteurs de stress de cellules en leur fournissant le polypeptide sauvage ou des polypeptides mutants exprimés par <u>LAG1</u> et dépourvus, par exemple, du domaine "limitant la durée de vie".

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