Method for promoting hematopoietic and mesenchymal cell...

Details Method for promoting hematopoietic and mesenchymal cell... Method for promoting hematopoietic and mesenchymal cell...

A - Human Necessities

61

K

A61K 38/08 (2006.01) C07K 7/14 (2006.01) C12N 5/06 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2278737

The present invention provides methods, improved cell culture medium and kits for promoting hematopoietic and mesenchymal stem and lineage-specific cell proliferation and differentiation by growth in the presence of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists, either alone or in combination with other growth factors and cytokines.

La présente invention concerne des procédés, un milieu de culture cellulaire amélioré, et des kits qui stimulent la prolifération et la différentiation de cellules souches hématopoïétiques et mésenchymateuses de lignage spécifique, par une croissance en présence d'un angiotensinogène, de l'angiotensine I (AI), d'analogues AI, de fragments AI et de leurs analogues, de l'angiotensine II (AII), d'analogues de AII, de fragments de AII ou de leurs analogues, ou d'agonistes récepteurs de AII AT¿2? type 2, ces hormones ou ces fragments étant seuls ou combinés à d'autres facteurs de croissance ou à d'autres cytokines.

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