Process for producing 6-(3-dimethylaminopropionyl)forskolin

Details Process for producing 6-(3-dimethylaminopropionyl)forskolin Process for producing 6-(3-dimethylaminopropionyl)forskolin

C - Chemistry, Metallurgy

07

D

C07D 311/92 (2006.01)

Patent

CA 2054419

A process for producing 6-(3-dimethylaminopropionyl)forskolin, the process comprising the sequential steps of: (1) acetylating hydroxy groups in 1-position and 7-position of a compound represented by the formula (III): (see formula I) to prepare 1-acetyl-6-(3-dimethylaminopropionyl)forskolin represented by the formula (II): (see formula II) wherein Ac represents acetyl group; and (2) selectively removing the acetyl group in the 1-position of the compound represented by the formula (II) in the presence of dimethylamine in a solvent, to prepare 6-(3-dimethylamino- propionyl)forskolin represented by the formula (I): (see formula III) This compound has promise as a therapeutic agent for cardiac failure.

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