Replication-deficient rna viruses as vaccines

Details Replication-deficient rna viruses as vaccines Replication-deficient rna viruses as vaccines

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/7088 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07K 14/115 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 15/33 (2006.01) C12N 15/45 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2599036

The invention relates to a genome replication-deficient and transcription- competent negative strand RNA virus which can be used for expressing transgenes and especially for developing vaccines. The viral genome contains a mutation in at least one of the genes N, L, or P.

La présente invention a trait à un virus ARN à brin négatif à réplication déficiente et à transcription compétente qui peut être utilisé pour l'expression de transgènes et particulièrement pour le développement de vaccins. Le génome viral contient une mutation dans au moins un des gènes N, L, ou P.

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