Modified proteins which bind extracellular matrix components

Details Modified proteins which bind extracellular matrix components Modified proteins which bind extracellular matrix components

C - Chemistry, Metallurgy

12

N

C12N 15/867 (2006.01) A61K 9/127 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 7/06 (2006.01) C07K 14/005 (2006.01) C07K 14/15 (2006.01) C07K 14/16 (2006.01) C07K 14/78 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/33 (2006.01) C12N 15/48 (2006.01) C12N 15/62 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2285937

A viral or non-viral vector particle having a modified viral surface protein wherein the viral surface protein is modified to include a targeting polypeptide including a binding region which binds to an extracellular matrix component. Such vector particles are useful in delivering genes encoding therapeutic agents to cells located at the site of an exposed extracellular matrix component.

L'invention a trait à une particule vecteur virale ou non virale possédant une protéine virale de surface, laquelle protéine a été modifiée pour recevoir un polypeptide ciblant pourvu d'un site de fixation se fixant à un composant de matrice extracellulaire. Ces particules vecteur sont utilisées s'agissant d'apporter des gènes codant des agents thérapeutiques à des cellules se trouvant sur le site d'un composant de matrice extracellulaire à découvert.

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