New hiv protease inhibitors

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 271/20 (2006.01) A61K 31/16 (2006.01) A61K 31/27 (2006.01) C07C 237/22 (2006.01) C07C 271/24 (2006.01) C07C 311/00 (2006.01) C07C 311/19 (2006.01) C07C 311/42 (2006.01) C07C 317/18 (2006.01) C07C 317/28 (2006.01) C07D 213/40 (2006.01) C07D 213/56 (2006.01) C07D 295/215 (2006.01) C07D 307/02 (2006.01) C07D 307/14 (2006.01) C07D 307/20 (2006.01) C07D 333/48 (2006.01) C07D 335/06 (2006.01)

Patent

CA 2193220

Oligopeptide analogs containing sulfonamide, urea or carbamate linkages in the backbone are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

Analogues oligopeptidiques contenant des liaisons carbamate, sulfonamide ou urée dans le squelette. Ces composés se prêtent à l'inhibition de la protéase de VIH, à la prévention ou au traitement d'une infection par VIH ainsi qu'au traitement du SIDA, sous forme de composés, de sels pharmaceutiquement acceptables ou de principes dans une composition pharmaceutique, éventuellement en association avec d'autres antiviraux, immunomodulateurs, antibiotiques ou vaccins. Des procédés de prévention ou de traitement d'une infection par VIH sont également décrits.

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