Thermally-processed cocoa products useful for vascular...

A - Human Necessities – 61 – K

Patent

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Details

A61K 36/185 (2006.01) A23G 1/00 (2006.01) A23L 2/38 (2006.01) A61K 31/353 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2611849

The invention relates to compositions containing polyphenols such as flavanols, procyanidins, and derivatives thereof obtainable by thermally treating the polyphenols in an aqueous solution, and to compositions comprising epimers of flavanols, procyanidins, and derivatives thereof, and methods of therapeutic or prophylactic treatment of NO-responsive diseases or disorders using the same. The invention also relates to thermally-processed cocoa powders and cocoa extracts characterized by an altered monomelic and oligomeric profile where the total amount of epicatechin and catechin is unchanged, where new dimers are present, and where oligomers higher than the trimers are absent.

L'invention concerne des compositions qui contiennent des polyphénols tels que les flavanols, les procyanidines, et des dérivés de ceux-ci obtenus par traitement thermique des polyphénols dans une solution aqueuse; des compositions qui contiennent des épimères de flavanols, de procyanidines, et des dérivés de ceux-ci; ainsi que des méthodes thérapeutiques ou prophylactiques des maladies ou de troubles réceptifs au monoxyde d'azote, qui font intervenir ces compositions. Par ailleurs, l'invention concerne des poudres et des extraits de cacao thermiquement traités caractérisés par un profil monomélique et oligomérique modifié, dans lesquelles la quantité totale de l'épicatéchine et de la catéchine reste inchangé, de nouveaux dimères sont présents, et des oligomères plus élevés que les trimères sont absents.

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