Indole derivatives useful for the treatment of cns disorders

Details Indole derivatives useful for the treatment of cns disorders Indole derivatives useful for the treatment of cns disorders

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/38 (2006.01) A61K 31/395 (2006.01) A61K 31/4045 (2006.01) A61K 31/4523 (2006.01) A61K 31/496 (2006.01) A61P 25/06 (2006.01) A61P 25/18 (2006.01) A61P 25/20 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) C07D 209/04 (2006.01) C07D 211/04 (2006.01) C07D 241/04 (2006.01) C07D 275/06 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2412141

The present invention relates to dopamine and serotonin receptor ligands having the general formula (I) wherein the meanings of Y, Z, W, n, m, X and R1- R12 are as given in the claims and the description. The compounds of the invention are useful in the treatment of certain psychiatric and neurological disorders, i. e. schizophrenia and other psychoses, anxiety disorders, depression, migraine, cognitive disorders, attention deficit hyperactivity disorder (ADHD) and sleep improvement.

L'invention concerne des ligands des récepteurs de la dopamine et de la sérotonine représentés par une formule générale (I) où : Y, Z, W, n, m, X et R?1¿-R?12¿ ont la signification donnée dans les revendications Ces composés servent au traitement de certains troubles psychiatriques et neurologiques, par exemple la schizophrénie et autres psychoses, les troubles anxieux, la dépression, la migraine, les troubles cognitifs, les troubles déficitaires de l'attention avec hyperactivité (TDAH), et servent également à l'amélioration du sommeil.

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