Human monoclonal antibodies to prostate specific membrane...

Details Human monoclonal antibodies to prostate specific membrane... Human monoclonal antibodies to prostate specific membrane...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 13/08 (2006.01) C07K 16/28 (2006.01) C12N 5/18 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2598522

The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PSMA with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecifÊc molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for treating cancer.

La présente invention concerne des anticorps monoclonaux isolés, notamment des anticorps monoclonaux humains qui se lient spécifiquement à l'antigène d'enveloppe spécifique de la prostate avec une forte affinité; des molécules d'acide nucléique qui codent les anticorps selon l'invention, des vecteurs d'expression, des cellules hôtes et des méthodes d'expression des anticorps selon l'invention; des immunoconjugués, des molécules bispécifiques et des compositions pharmaceutiques comprenant les anticorps selon l'invention; ainsi que des méthodes de traitement du cancer. .

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