Pharmaceutical composition for the treatment of nail diseases

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/00 (2006.01) A61K 31/137 (2006.01)

Patent

CA 2640889

A method for topically and systemically delivering a pharmaceutical composition to a human nail is disclosed, said method comprising the application of a pharmaceutical composition to the nail, covering the nail and the pharmaceutical composition with a protective layer, and a dissolvent to remove the protective layer and the pharmaceutical composition after a certain time of action and before reapplication. Preferably the method is combined with a laser pretreatment of the nail to drill arrays of partial orifices to enhance the permeability of drugs through the nail plate.

La présente invention a pour objet une méthode de libération locale et systémique d'une préparation pharmaceutique au niveau d'un ongle humain, ladite méthode comprenant l'application d'une préparation pharmaceutique à l'ongle, le recouvrement de l~ongle et de la préparation pharmaceutique par une couche protectrice, ainsi qu'un dissolvant permettant de retirer la couche protectrice et la préparation pharmaceutique après un temps d'action donné et avant réapplication. De façon préférentielle, la méthode est combinée à un prétraitement au laser de l'ongle pour former des ensembles d'orifices partiels, ceci afin d'augmenter la perméabilité des médicaments au travers du plat de l'ongle.

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