Carbonic anhydrase ix (g250) antibodies and methods of use...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 16/40 (2006.01) A61K 35/14 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C07K 14/55 (2006.01) C07K 14/705 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/13 (2006.01) C12N 15/26 (2006.01) C12N 15/62 (2006.01) C12N 15/85 (2006.01) G01N 33/563 (2006.01) G01N 33/573 (2006.01) G01N 33/577 (2006.01) C12N 9/86 (2006.01)

Patent

CA 2632094

The invention provides scFv antibodies and monoclonal antibodies that bind to and decrease an activity of Carbonic Anhydrase IX (G250). Also provided are methods of treating and/or preventing cancer, such as renal clear cell cancer. Also provided are methods of identifying a carbonic anhydrase IX (G250) protein. The invention additionally provides methods of modifying immune effector cells, and the immune effector cells modified thereby.

La présente invention concerne des anticorps sdFv et des anticorps monoclonaux se liant à l'anhydrase carbonique IX (G250) dont ils diminuent l'activité. L'invention concerne également des procédés permettant de traiter et/ou prévenir le cancer tel que le cancer rénal à cellules claires. L'invention concerne aussi des procédés permettant d'identifier une protéine à anhydrase carbonique IX (G250). L'invention concerne en outre, d'une part des procédés permettant de modifier les cellules effectrices de l'immunité, et d'autre part ces cellules ainsi modifiées.

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