Benzimidazole and indole derivatives as crf receptor modulators

Details Benzimidazole and indole derivatives as crf receptor modulators Benzimidazole and indole derivatives as crf receptor modulators

C - Chemistry, Metallurgy

07

D

C07D 235/14 (2006.01) A61K 31/4184 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61P 25/00 (2006.01) C07D 209/14 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 521/00 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2425185

Benzimidazole and indole derivatives of the formula (I) that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and peripheral disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.

La présente invention concerne des dérivés de formule (I) agissant comme modulateurs des récepteurs de la corticolibérine. Ces composés sont utiles dans le traitement de certains troubles du système nerveux central et périphérique, notamment le stress, l'anxiété, la dépression, les troubles cardio-vasculaires, et les troubles alimentaires. L'invention concerne également des procédés de traitement de tels troubles ainsi que des compositions pharmaceutiques conditionnées. Les composés de l'invention sont également utiles en tant que sondes pour la localisation des récepteurs de la corticolibérine et en tant que normes dans des dosages pour la fixation des récepteurs de la corticolibérine. Enfin, l'invention propose des procédés pour la mise en oeuvre des composés dans des études de localisation de récepteurs.

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