Use of nitric oxide scavengers to treat side effects caused...

A - Human Necessities – 61 – K

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Details

A61K 31/325 (2006.01) A01N 43/42 (2006.01) A61K 31/137 (2006.01) A61K 31/16 (2006.01) A61K 31/194 (2006.01) A61K 31/4162 (2006.01) A61K 31/4164 (2006.01) A61K 31/444 (2006.01) A61K 31/445 (2006.01) A61K 31/4745 (2006.01) A61K 31/495 (2006.01)

Patent

CA 2334973

Nitric oxide scavengers, such as dithiocarbamate-containing compounds, are used to reduce side effects caused by therapeutic administration of nitric oxide sources by administering the nitric oxide scavenger(s) to the subject after the therapeutic effect of the nitric oxide source has been achieved. For example, the nitric oxide source can be coadministered with the nitric oxide scavenger, with the latter formulated in a time release vehicle selected to delay release of the scavenger for a period of time sufficient to ensure that the therapeutic goal of the nitric oxide source has been achieved before release of the scavenger. Formulations and kits, including a bubble pack with pairwise arrangement of unit doses of a desired nitric oxide source and nitric oxide scavenger, are also provided. The side effects of sildenafil citrate (Viagra), or of simultaneous administration of such a nitric oxide source in combination with another, such as nitroglycerin, are effectively controlled by the methods, formulations and kits of the invention.

On utilise des capteurs d'oxyde nitrique, tels que des composés contenant dithiocarbamate, afin de limiter les effets secondaires provoqués par l'administration thérapeutique de sources d'oxyde nitrique, ce qui consiste à administrer ce ou ces capteurs d'oxyde nitrique à un individu après l'obtention de l'effet thérapeutique de la source d'oxyde nitrique. On peut, par exemple, administrer la source d'oxyde nitrique conjointement avec le capteur d'oxyde nitrique, ce dernier étant formulé dans un véhicule à libération prolongée sélectionné de manière à libérer le capteur avec un effet retard pendant une durée suffisante pour l'obtention de la finalité thérapeutique de la source d'oxyde nitrique. L'invention concerne également des formulations et des trousses, y compris une plaquette alvéolaire contenant des paires de doses unitaires de source souhaitée d'oxyde nitrique et de capteur d'oxyde nitrique. Ces procédés, ces formulations et ces trousses permettent de limiter efficacement les effets secondaires de sildenalfil citrate (Viagra?) ou de l'administration simultanée de ce type de source d'oxyde nitrique et de, par exemple, de la nitroglycérine.

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