Melanoma antigens

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 39/00 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2188432

The present invention provides a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated MART-1. This invention further relates to bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess or prognose a mammal afflicted with melanoma or metastata melanoma. This invention also provides immunogenic peptides derived from the MART-1 melanoma antigen and a second melanoma antigen designated gp100. This invention further provides immunogenic peptides derived from the MART-1 melanoma antigen or gp100 antigen which have been modified to enhance their immunogenicity. The proteins and peptides provided can serve as an immunogen or vaccine to prevent or treat melanoma.

L'invention porte sur une séquence d'acide nucléique codant un antigène du mélanome appelé MART-1 reconnu par les lymphocytes T, et sur des dosages biologiques recourant à la séquence d'acide nucléique, à la protéine et aux anticorps objets de ladite invention pour diagnostiquer, évaluer ou pronostiquer le mélanome ou le mélange métastatique chez un mammifère. L'invention porte également sur des peptides immunogènes dérivés de l'antigènedu mélanome MART-1 et sur un second antigène du mélanome appelé gp100; elle porte en outre sur des peptides immunogènes dérivés de l'antigène du mélanome MART-1 ou de l'antigène gp100 modifiés pour accroître leur capacité immunogène. Lesdits protéines et peptides peuvent servir d'immunogène ou de vaccin pour la prévention et le traitement du mélanome.

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