Extracellular/epidermal growth factor hcaba58x

Details Extracellular/epidermal growth factor hcaba58x Extracellular/epidermal growth factor hcaba58x

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 31/70 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07K 14/485 (2006.01) C07K 16/22 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2250268

The present invention discloses an extracellular/epidermal growth factor polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include induction of cell growth and differentiation, stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders, treating Marfan syndrome and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia and diabetes. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.

L'invention porte sur des polypeptides du facteur de croissance extracellulaire/épidermique et sur des polynucléotides codant ces polypeptides. Elle porte sur un procédé pour produire de tels polypeptides au moyen de techniques recombinantes et des applications thérapeutiques de ces polypeptides, comprenant l'induction de la croissance et de la différenciation cellulaires, la stimulation de la cicatrisation, le traitement de troubles neurologiques, le traitement de problèmes oculaires, rénaux, ou hépatiques, le traitement du syndrome de Marfan, ainsi que la stimulation de l'embryogenèse et de l'angiogenèse. L'invention se rapporte en outre à des antagonistes dirigés contre ces polypeptides et leur utilisation thérapeutique dans le traitement de la néoplasie et du diabète. Sont également décrites des méthodes diagnostiques pour détecter les variations du taux de ces polypeptides et les mutations intervenant dans les séquences nucléotidiques codant les polypeptides selon l'invention.

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