C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 323/49 (2006.01) A61K 31/18 (2006.01) A61K 31/33 (2006.01) A61K 31/66 (2006.01) C07C 391/02 (2006.01) C07D 213/56 (2006.01) C07D 295/22 (2006.01) C07D 307/00 (2006.01) C07D 333/34 (2006.01) C07F 9/12 (2006.01)
Patent
CA 2190472
HIV protease inhibitors of formula (1), in which Q1 to Q8, E, and Y are as defined in Claim 1, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
Inhibiteurs de protéase du virus de l'immunodéficience humaine (VIH) répondant à la formule (1), dans laquelle Q¿1? à Q¿8?, E et Y sont tels que définis dans la revendication 1. Ces inhibiteurs s'obtiennent par synthèse chimique, et inhibent ou bloquent l'activité biologique de la protéase du VIH, interrompant ainsi la réplication du virus VIH. Ces composés, ainsi que les compositions pharmaceutiques qui contiennent lesdits composés et, éventuellement, d'autres agents antiviraux comme principes actifs, conviennent au traitement de patients ou hôtes infectés par le virus VIH, dont on sait qu'il provoque le syndrome d'immunodéficience acquise (SIDA).
Agouron Pharmaceuticals Inc.
Sim & Mcburney
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