Methods of using death receptor agonists and egfr inhibitors

Details Methods of using death receptor agonists and egfr inhibitors Methods of using death receptor agonists and egfr inhibitors

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 31/517 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2595931

Methods for using death receptor ligands, such as Apo-2 ligand/TRAIL polypeptides or death receptor antibodies, and EGFR inhibitors to treat pathological conditions such as cancer are provided. Embodiments of the invention include methods of using Apo2L/TRAIL or death receptor antibodies such as DR5 antibodies and DR4 antibodies in combination with EGFR inhibitors, such as TarcevaTM .

L'invention concerne des méthodes d'utilisation de ligands de récepteurs de mort, tels que des polypeptides ligands APO-2/TRAIL ou des anticorps de récepteurs de mort, ainsi que d'inhibiteurs d'EGFR pour traiter des états pathologiques tels que le cancer. Dans des modes de réalisation, l'invention concerne des méthodes d'utilisation d'Apo2L/TRAIL ou d'anticorps de récepteurs de mort tels que des anticorps DR5 et des anticorps DR4 en combinaison avec des inhibiteurs d'EGFR, tels que TarcevaTM .

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