Pharmaceutical composition comprising a cytokine

A - Human Necessities – 61 – K

Patent

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Details

IPC codes

A61K 38/19 (2006.01) A61K 31/454 (2006.01) A61K 31/515 (2006.01) A61K 31/519 (2006.01) A61K 31/53 (2006.01) A61P 31/18 (2006.01)

Type

Patent

Patent number

CA 2682050

Description

The present invention relates to a pharmaceutical composition comprising, (i) a cytokine and, (ii) a compound of the general formula (Qi) or pharmaceutically acceptable salts thereof with an acid or a base, or pharmaceutically acceptable prodrugs or a stereoisomer thereof. Exemplary cytokines are selected from the following group of cytokine families, (i) the four .alpha.-helix bundle family, which consists of, (a) the the IL-2 subfamily, (b) the interferon (IFN) subfamily and, (c) the IL-IO subfamily, (ii) the IL-I family, (iii) the IL- 17 family and, (iv) chemokines.

La présente invention concerne une composition pharmaceutique comprenant (i) une cytokine et (ii) un composé de formule générale (Qi) ou un de ses sels pharmaceutiquement acceptables avec un acide ou une base, ou encore des promédicaments pharmaceutiquement acceptables ou un stéréoisomère dudit composé. Les cytokines sont, par exemple, sélectionnées dans le groupe des familles de cytokines suivant : (i) la famille à barillet de quatre hélices .alpha., qui est constituée par (a) la sous-famille des IL-2, (b) la sous-famille des interférons (IFN) et, (c) la sous-famille des IL-IO, (ii) la famille des IL-I, (iii) la famille des IL- 17 et, (iv) les chémokines.

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