Use of umbilical cord blood to treat individuals having a...

A - Human Necessities – 61 – K

Patent

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Details

A61K 35/44 (2006.01) A61K 35/14 (2006.01) A61P 7/00 (2006.01) C12N 5/073 (2010.01)

Patent

CA 2515594

The present invention provides methods of using cord blood and cord blood- derived stem cells in high doses to treat various conditions, diseases and disorders. The high-dose cord blood and cord blood-derived stem cells have a multitude of uses and applications including but not limited to, therapeutic uses for transplantation and treatment and prevention of disease, and diagnostic and research uses. In particular, the cord blood or cord blood- derived stem cells are delivered in high doses, e.g., at least 3 billion nucleated cells per treatment, where treatment may comprise a single or multiple infusions. The invention also provides for the use of cord blood or cord blood-derived stem cells from multiple donors without the need for HLA typing.

La présente invention concerne des méthodes d'utilisation de sang de cordon ombilical et de cellules souches issues de sang de cordon ombilical à hautes doses afin de traiter plusieurs pathologies, maladies et troubles. Le sang de cordon ombilical et les cellules souches issues de sang de cordon ombilical à haute dose présente une multitude d'utilisations et d'applications comprenant, mais ne se limitant pas à, des utilisations thérapeutiques à des fins de greffe, de traitement et de prévention de maladies, ainsi qu'à des fins de diagnostic et de recherche. En particulier, le sang de cordon ombilical ou les cellules souches issues de sang de cordon ombilical sont administrées à hautes doses, par exemple, au moins 3 milliards de cellules nucléées par traitement, ledit traitement pouvant comprendre une perfusion unique ou plusieurs perfusions. L'invention concerne également l'utilisation de sang de cordon ombilical ou de cellules souches issues de sang de cordon ombilical de plusieurs donneurs sans recours au typage HLA.

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