C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/30 (2006.01) A61K 39/015 (2006.01) A61P 33/06 (2006.01) C07K 14/445 (2006.01) C07K 16/20 (2006.01) C12N 15/62 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2337754
A recombinant protein is provided which comprises peptides derived from different stages in the life cycle of the parasite Plasmodium falciparum. The protein is useful as a reagent and, when combined with a pharmaceutically- acceptable vehicle or carrier, is useful as a vaccine against the malarial parasite Plasmodium falciparum. A genetic construct used to produce this recombinant protein vaccine is also described. In addition, antibodies to this recombinant protein are provided which are useful for the detection and measurement of peptides derived from different stages in the life cycle of the parasite Plasmodium falciparum.
L'invention concerne une protéine recombinante qui comprend des peptides provenant de différents stades du cycle de vie du parasite Plasmodium falciparum. La protéine est utile en tant que réactif; combinée à un vecteur ou à un excipient pharmaceutiquement acceptables, elle peut servir de vaccin contre le parasite paludéen Plasmodium falciparum. Une construction génétique est utilisée pour produire ce vaccin à base de protéine recombinante. En outre, l'invention concerne des anticorps de cette protéine recombinante, utiles pour la détection et la mesure de peptides provenant de différents stades du cycle de vie du parasite Plasmodium falciparum.
Hasnain Seyed E.
Lal Altaf A.
Shi Ya Ping
Department Of Health And Human Services The Government Of The United States Of America As Represented By
National Institute Of Immunology
Smart & Biggar
LandOfFree
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