Novel cd19xcd3 specific polypeptides and uses thereof

Details Novel cd19xcd3 specific polypeptides and uses thereof Novel cd19xcd3 specific polypeptides and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2326389

Described are novel single-chain multifunctional polypeptides comprising at least two binding sites specific for the CD19 and CD3 antigen, respectively. Further provided are polypeptides, wherein the above- described polypeptide comprises at least one further domain, preferably of pre-determined function. Furthermore, polynucleotides encoding said polypeptides as well as to vectors comprising said polynucleotides and host cells transformed therewith and their use in the production of said polypeptides are described, In addition, compositions, preferably pharmaceutical and diagnostic compositions are provided comprising any of the afore-described polypeptides, polynucleotides or vectors. Described is also the use of the afore-mentioned polypeptides, polynucleotides and vectors for the preparation of pharmaceutical compositions for immunotherapy, preferably against B-cell malignancies such as non-Hodgkin lymphoma.

L'invention concerne de nouveaux polypeptides multifonctionnels à une chaîne, comprenant au moins deux sites de liaison respectivement spécifiques aux antigènes CD19 et CD3. L'invention concerne également des polypeptides dans lesquels les polypeptides susmentionnés renferment au moins un domaine supplémentaire, de préférence d'une fonction prédéfinie. L'invention concerne en outre les polynucléotides codant pour ces polypeptides, les vecteurs comprenant ces polynucléotides et les cellules hôtes transformées à l'aide de ces polynucléotides, ainsi que leur utilisation dans la production desdits polypeptides. Cette invention concerne par ailleurs des compositions, de préférence pharmaceutiques et diagnostiques, renfermant l'un des polypeptides, polynucléotides, ou vecteurs susmentionnés. L'invention concerne enfin l'utilisation des polypeptides, polynucléotides, ou vecteurs susmentionnés pour préparer des compositions pharmaceutiques destinées à être utilisées en immunothérapie, de préférence contre les cellules B malignes, par exemple le lymphome non hodgkinien.

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