Tricyclic antitumor compounds being farnesyl protein...

Details Tricyclic antitumor compounds being farnesyl protein... Tricyclic antitumor compounds being farnesyl protein...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/55 (2006.01) C07D 221/16 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2266015

The invention relates to tricyclic compounds of formula (1.0) wherein R1, R2, R3, R4, R5, R6, R7, R8, Y, A, B, X, a, b, c, d, v, and w are as described herein. The compounds of formula (1.0) are useful for inhibiting tumor growth being farnesyl protein transferase inhibitors.

L'invention porte sur des composés tricyclique de formule (1.0) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, Y, A, B, X, a, b, c, d, v et w sont définis dans la description. Lesdits composés inhibent la croissance tumorale du fait de leur rôle d'inhibiteurs de la farnésyl transférase protéique.

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