Nucleic acid respiratory syncytial virus vaccines

Details Nucleic acid respiratory syncytial virus vaccines Nucleic acid respiratory syncytial virus vaccines

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 31/70 (2006.01) A61K 39/155 (2006.01) A61K 39/385 (2006.01) A61K 48/00 (2006.01) C07K 14/135 (2006.01) C07K 16/10 (2006.01) C12N 15/12 (2006.01) C12N 15/45 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2223610

Vectors containing a nucleotide sequence coding for an F protein of respiratory syncytial virus (RSV) and a promoter for such sequence, preferably a cytomegalovirus promoter, are described. Such vectors also may contain a further nucleotide sequence located adjacent to the RSV F protein encoding sequence to enhance the immunoprotective ability of the RSV F protein when expressed in vivo. Such vectors may be used to immunize a host, including a human host, by administration thereto. Such vectors also may be used to produce antibodies for detection of RSV infection in a sample.

L'invention concerne des vecteurs qui contiennent une séquence de nucléotides codant une protéine F du virus respiratoire syncytial et un promoteur de cette séquence, de préférence un promoteur de cytomégalovirus. Ces vecteurs peuvent également contenir une séquence supplémentaire de nucléotides adjacente à la séquence codant la protéine F du virus respiratoire syncytial afin d'améliorer la capacité immunoprotectrice de la protéine F du virus respiratoire syncytial exprimée in vivo. On peut administrer ces vecteurs à un hôte, y compris à un hôte humain, pour l'immuniser. On peut également utiliser ces vecteurs pour produire des anticorps pour détecter l'infection par le virus respiratoire syncytial dans un échantillon.

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