Process for the production of carboxanilides

Details Process for the production of carboxanilides Process for the production of carboxanilides

C - Chemistry, Metallurgy

07

D

C07D 231/14 (2006.01)

Patent

CA 2627365

The present invention relates to a novel process for the preparation of a compound of general formula (I): wherein R1 is H or C1-4 alkyl and R2 is difluoromethyl or trifluoromethyl, which comprises reacting a compound of general formula (II): wherein R1 has the meaning given above and X is chloro or bromo, with a compound of general formula (III): wherein R2 has the meaning given above, in the presence of a base, a palladium catalyst and a ferrocenyl biphoshine ligand of the Josiphos type, the reaction being carried out in an ether solvent at a reflux temperature of at least 100 ~C.

L'invention concerne un nouveau procédé de préparation d'un composé de formule générale (I): R1 représente H ou un alkyle en C1-4 et R2 représente un difluorométhyle ou un trifluorométhyle, qui consiste à mettre en réaction un composé de formule générale (II); R1 a la signification donnée ci-dessus, en présence d'une base, d'un catalyseur de palladium et d'un ligand de biphoshine ferrocényle de type Josiphos, la réaction étant réalisée dans un solvant d'éther à une température de reflux d'au moins 100 °C.

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