Spirocyclic benzopyran imidazolines

Details Spirocyclic benzopyran imidazolines Spirocyclic benzopyran imidazolines

C - Chemistry, Metallurgy

07

D

C07D 491/107 (2006.01) A61K 31/415 (2006.01) C07D 491/10 (2006.01)

Patent

CA 2113818

2113818 9305045 PCTABS00020 Spiro-[4H-1-benzopyran-4,4'-5'H-imidazol]-5'-ones of Formula (1), wherein R1 is H, R2, F, Cl, Br, CF3, CF3O, CN, NO2, R2SO2, R2NHSO2, R2O, R2CO, R2OCO, or R2NHCO. R2 is a C1-C10 branched or linear alkyl, a C3-8 cycloalkyl, phenyl, or benzyl. X can be S, O, or NH. Both enantiomers are included in this invention as well as salts and tautomeric forms of these compounds. The subject compounds are useful in the treatment of hypertension, alopecia, and erectile dysfunction.

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