C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61P 3/10 (2006.01) C07K 14/485 (2006.01) C12N 5/10 (2006.01) C12N 15/18 (2006.01) C12N 15/88 (2006.01)
Patent
CA 2700360
The present invention includes compositions and methods for transforming cells into glucose- responsive, insulin--production cells using a construct that expresses betacellulin and PDXI, e.g., transforming pancreatic acinar cells using one or more expression vectors that expressed betacellulin and PDXI using ultrasound targeted microbubble destruction (UTMD).
La présente invention concerne des compositions et procédés servant à transformer des cellules en cellules de production d'insuline sensibles au glucose, en utilisant une construction génique qui exprime la betacelluline et le facteur de transcription PDX1, par exemple à transformer des cellules acinaires pancréatiques en utilisant un ou plusieurs vecteurs d'expression qui expriment la betacelluline et le PDX1 en utilisant la destruction ciblée de microbulles par des ultrasons (UTMD).
Chen Shuyuan
Grayburn Paul A.
Baylor Research Institute
Shapiro Cohen
LandOfFree
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