C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/543 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2427902
Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.
L'invention concerne des compositions et des méthodes destinées à la thérapie et au diagnostic du cancer, en particulier le cancer de l'ovaire. Des compositions de la présente invention comprennent un ou plusieurs polypeptides tumoraux ovariens, des portions immunogènes de ces derniers, des polynucléotides codant ces polypeptides, une cellule présentatrice de l'antigène exprimant ces polypeptides, et des lymphocytes T spécifiques pour des cellules exprimant ces polypeptides. Ces compositions sont utiles, par exemple, pour le diagnostic, la préventions et/ou le traitement de pathologies, en particulier le cancer de l'ovaire.
Algate Paul A.
Fling Steven P.
Molesh David Alan
Stolk John A.
Xu Jiangchun
Corixa Corporation
Gowling Lafleur Henderson Llp
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