C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/58 (2006.01) A61K 31/4545 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2674237
The present invention provides N-substituted-heterocycloalkyloxybenzamide compounds, as well as pharmaceutical compositions and methods of use. One embodiment of the invention is a compound having the structure (I), in which R1, R2, R3, R4, T, n, w and x are as described herein. In certain embodiments of the invention, a compound of the present invention activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.
L'invention concerne la fourniture de composés d'hétérocycloalkyloxybenzamide N-substitués, ainsi que des compositions pharmaceutiques et des procédés d'utilisation. Un mode de réalisation de la présente invention est un composé ayant la structure (I), dans laquelle R1, R2, R3, R4, T, n, w et x sont tels que décrits dans le présent document. Dans certains modes de réalisation de la présente invention, un composé selon la présente invention active la voie AMPK, et peut être utilisé pour traiter des troubles et des états d'origine métabolique.
Darwish Ihab S.
Hong Hui
Singh Rajinder
Thota Sambaiah
Xu Xiang
Mbm Intellectual Property Law Llp
Rigel Pharmaceuticals Inc.
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