Use of complement pathway inhibitors to treat ocular diseases

Details Use of complement pathway inhibitors to treat ocular diseases Use of complement pathway inhibitors to treat ocular diseases

A - Human Necessities

61

K

A61K 38/00 (2006.01) C07K 17/00 (2006.01)

Patent

CA 2624393

The present invention relates to the treatment of ocular diseases and conditions by administering a complement pathway inhibitor, particularly an alternative pathway inhibitor. Ocular diseases include age-related macular degeneration, diabetic retinopathy, and ocular angiogenesis. One embodiment comprises the administration of an anti-Factor D antibody in the form of a whole antibody, a Fab fragment or a single domain antibody. Other complement component inhibitors that may be useful in the present method include Factor H or inhibitors that block the action of properdin, factor B, factor Ba, factor Bb, C2, C2a, C3a, C5, C5a, C5b, C6, C7, C8, C9, or C5b-9.

La présente invention concerne le traitement de maladies et affections oculaires en administrant un inhibiteur de la voie du complément, en particulier un inhibiteur de la voie alterne. Les maladies oculaires comprennent la dégénérescence maculaire liée à l'âge, la rétinopathie diabétique et l'angiogenèse oculaire. Un mode de réalisation comprend l'administration d'un anticorps anti-facteur D sous la forme d'un anticorps entier, d'un fragment Fab ou d'un anticorps à un seul domaine. D'autres inhibiteurs du composant complément qui peuvent être utiles dans le présent procédé comprennent le facteur H ou des inhibiteurs qui bloquent l'action de la properdine, du facteur B, du facteur Ba, du facteur Bb, du C2, du C2a, du C3a, du C5, du C5a, du C5b, du C6, du C7, du C8, du C9 ou du C5b-9.

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