C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/50 (2006.01) C07D 401/04 (2006.01)
Patent
CA 2307979
This invention relates to: (1) a compound represented by the formula (V), its tautomer and a mixture of the same; (2) a process for producing the compound represented by the above-mentioned formula (V), its tautomer or a mixture of the same, which comprises reacting N-vinylpiperidone represented by the formula (I) with a nicotinate represented by the formula (II), wherein R represents a lower alkyl group, in the presence of a sodium alkoxide; (3) a process for producing a pyridine derivative represented by the formula (III), which comprises producing the compound represented by the formula (V), its tautomer or a mixture of the same by the process as described in the above (2), and then treating the obtained compound with an acid; and (4) a process for producing a pyridine derivative represented by the formula (IV), in which the treatment with an acid as described in the above (3) is followed by another treatment with a base. Thus, the present invention provides industrial processes for producing pyridine derivatives represented by the formulae (III) and (IV) safely, economically, easily and efficiently without using any hazardous reagents. (See formulae I, II, III) (See formulae IV , V)
Kajitani Makoto
Kem William R.
Lee Hun Ju
Maruhashi Kazuo
Watanabe Syotaro
G. Ronald Bell & Associates
Taiho Pharmaceutical Co. Ltd.
University Of Florida
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