C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 9/70 (2006.01) A61K 38/18 (2006.01) A61K 47/02 (2006.01) A61K 47/12 (2006.01) A61P 25/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/475 (2006.01) C07K 14/54 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 15/12 (2006.01) A61K 38/00 (2006.01) A61K 38/11 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2437263
The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of human brain-derived neutrophic factor (BDNF) to result in BDNF proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.
La présente invention concerne des polypeptides spécialement destinés à être administrés à des humains et, en particulier, à des fins thérapeutiques. Ces polypeptides sont des polypeptides modifiés, dont la modification génère une propension réduite du polypeptide à éliciter une réponse immunitaire suite à l'administration au sujet humain. L'invention concerne, en particulier, la modification du facteur neurotrophique humain BDNF, permettant d'obtenir des protéines BDNF sensiblement non immunogènes ou moins immunogènes qu'un quelconque homologue non modifié au cours d'une utilisation in vivo.
Carr Francis J.
Carter Graham
Jones Tim
Williams Stephen
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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