Nanotubes as mitochondrial uncouplers

A - Human Necessities – 61 – K

Patent

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Details

A61K 33/24 (2006.01) A61K 33/38 (2006.01) A61K 33/44 (2006.01)

Patent

CA 2646106

A method of uncoupling mitochondria in a subject including administering nanotubes to the subject in a therapeutically effective amount, wherein the nanotubes are self-rectifying is provided. A method of decreasing reactive oxygen species and decreasing detrimental loading of Ca2+ into mitochondria is provided, including administering a pharmaceutically effective amount of nanotubes into the subject. A method of reducing weight, treating cancer, reducing the effects of traumatic brain injury, or reducing the effects of ageing, in a subject including administering a pharmaceutically effective amount of nanotubes into the subject is also provided.

La présente invention concerne un procédé permettant de découpler les mitochondries dans un sujet par administration au sujet de nanotubes en quantité suffisante, les nanotubes étant autoredresseurs. L'invention concerne également un procédé de réduction des espèces réagissant à l'oxygène et de réduction de la charge nuisible de Ca2+ dans les mitochondries par administration au sujet de nanotubes en quantité suffisante. L'invention concerne enfin un procédé permettant de réduire le poids, de traiter le cancer, de réduire les effets des lésions encéphaliques, ou de réduire les effets du vieillissement chez un sujet par administration à ce sujet de nanotubes en quantité suffisante.

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