C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/58 (2006.01) C07C 311/29 (2006.01) C07C 317/24 (2006.01)
Patent
CA 2278241
Compounds useful in the treatment of cyclooxygenase-2 mediated diseases are provided of formula (I): (see formula I) wherein R1 is selected from the group consisting of (a) S(O)2CH3, and (b) S(O)2NH2, and R2 is unsubstituted, mono or di- substituted phenyl wherein the substituents are selected from the group consisting of halo, methoxy, methyl, said halo being selected from the group consisting of fluoro, chloro and bromo; the compounds (I) are produced in a process of treating in a non-aqueous polar solvent a compound of formula (A) (see formula A) wherein R1 and R2 are as defined above, in the presence of a strong base; to yield said compound of formula (I).
Ducharme Yves
Gauthier Jacques Yves
Leblanc Yves
Leger Serge
Prasit Petpiboon
Merck Frosst Canada & Co.
Merck Frosst Company
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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