Methods of predicting a benefit of antioxidant therapy for...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2512499

A method of determining a potential of a diabetic patient to benefit from anti oxidant therapy for treatment of a vascular complication, the method comprising determining a haptoglobin phenotype of the diabetic patient and thereby determining the potential of the diabetic patient to benefit from said anti oxidant therapy, whereby a patient having a haptoglobin 2-2 phenotype benefits from anti oxidant therapy more than a patient having a haptoglobin 1- 2 phenotype or a patient having a haptoglobin 1-1 phenotype.

L'invention concerne une méthode permettant de déterminer le potentiel d'un patient diabétique à tirer bénéfice d'un traitement antioxydant pour le traitement d'une complication vasculaire, ladite méthode consistant à déterminer un phénotype de l'haptoglobine du patient diabétique et à déterminer ainsi le potentiel du patient diabétique à tirer bénéfice dudit traitement antioxydant, un traitement antioxydant bénéficiant davantage à un patient présentant un phénotype de l'haptoglobine 2-2 qu'à un patient présentant un phénotype de l'haptoglobine 1-2 ou qu'à un patient présentant un phénotype de l'haptoglobine 1-1.

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