C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12N 15/09 (2006.01) C12P 19/34 (2006.01) C40B 30/04 (2006.01) C40B 40/06 (2006.01) C40B 50/06 (2006.01)
Patent
CA 2691360
The present invention provides methods for cancer detection and diagnosis. The present invention provides a method of selectively amplifying hypomethylated tumor DNA sequences derived from a subject for detection of cancer. This method utilizes differential methylation to allow for the selective amplification of tumor specific sequences from DNA mixtures that contain a high proportion of normal host DNA. The invention also provides methods of using the amplified tumor DNA sequences for evaluation of methylation.
L'invention concerne des procédés permettant de détecter et de diagnostiquer un cancer. Elle concerne un procédé d'amplification sélective de séquences d'ADN de tumeur hypométhylées provenant d'un sujet en vue de détecter un cancer. Ce procédé utilise une méthylation différentielle pour permettre d'amplifier sélectivement des séquences spécifiques de tumeur provenant de mélanges d'ADN qui contiennent une proportion élevée d'ADN hôte normal. L'invention concerne aussi des procédés d'utilisation des séquences d'ADN de tumeur amplifiées en vue d'évaluer la méthylation.
Brown Stephen A.
Gowling Lafleur Henderson Llp
The Trustees Of Columbia University In The City Of New York
LandOfFree
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