C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) C07K 5/103 (2006.01) C07K 5/117 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/245 (2006.01) C07K 14/435 (2006.01) C07K 19/00 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/94 (2006.01)
Patent
CA 2254853
A method for screening compounds for antimicrobial activity is described that utilizes bacterial protein-protein binding in vitro. The method may be performed using immobilized elements and the immobilization may be carried out using a variety of immobilization means e.g., columns, beads, adsorbents, nitrocellulose paper, etc.) in order to screen large libraries of compounds.
La présente invention concerne un procédé permettant de cribler des composés pour détecter leur activité antimicrobienne. Ledit procédé fait appel au pouvoir de liaison de protéines bactériennes avec des protéines in vitro. Ce procédé peut être mis en oeuvre sur des éléments immobilisés, l'immobilisation pouvant être obtenue par différents moyens d'immobilisation (par exemple des colonnes, des billes, des adsorbants, du papier de nitrocellulose, etc.) afin de cribler de grandes bibliothèques de composés.
de Boer Piet A. J.
Hale Cynthia A.
Case Western Reserve University
Smart & Biggar
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