Glucuronidated acetaminophen as a marker of hepatic disorders

G - Physics – 01 – N

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G01N 33/94 (2006.01)

Patent

CA 2738210

The present invention provides methods for diagnosing human hepatic disorders, such as non-alcoholic steatohepatitis (NASH), identifying a human subject at risk of an adverse drug reaction, and determining an appropriate dosage of a therapeutic drug for a human subject. The marker is an increased level of acetaminophen-glucuronide in a plasma or urine sample from a human subject.

La présente invention concerne des méthodes pour diagnostiquer des troubles hépatiques humains, tels que la stéatohépatite non alcoolique (NASH), identifier un sujet humain présentant un risque de réaction indésirable à un médicament, et déterminer une dose appropriée d'un médicament thérapeutique pour un sujet humain. Le marqueur est un taux accru d'acétaminophène-glucuronide dans un échantillon de plasma ou d'urine d'un sujet humain.

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