Process for the preparation of (2r,3s)-3-phenylisoserine...

Details Process for the preparation of (2r,3s)-3-phenylisoserine... Process for the preparation of (2r,3s)-3-phenylisoserine...

C - Chemistry, Metallurgy

07

C

C07C 237/20 (2006.01) C07C 227/18 (2006.01) C07C 227/30 (2006.01) C07C 229/34 (2006.01)

Patent

CA 2679159

A process for the enantioselective preparation of (2R,3S)-3-phenylisoserine methyl ester acetate salt of formula (I) which is an useful building block for the synthesis of taxane derivatives. The process involves the resolution of racemic threo-phenylisoserine amide and its conversion into (I).

L'invention concerne un procédé destiné à la préparation énantiosélective d'un sel d'acétate d'ester de méthyle de (2R,3S)-3-phénylisosérine représenté par la formule générale (I). Ce sel est un motif structural utile dans la synthèse de dérivés de taxane. Le procédé comprend la résolution d'un amide de thréo-phénylisosérine racémique et sa conversion pour obtenir la formule générale (I).

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