Hcv fusion proteins with modified ns3 domains

Details Hcv fusion proteins with modified ns3 domains Hcv fusion proteins with modified ns3 domains

C - Chemistry, Metallurgy

12

N

C12N 15/51 (2006.01) A61K 39/29 (2006.01) A61P 31/14 (2006.01) C07K 14/18 (2006.01) C12N 15/62 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2491508

The invention provides HCV fusion proteins that include a mutated NS3 protease domain, fused to at least one other HCV epitope derived from another region of the HCV polyprotein. The fusions can be used in methods of stimulating a cellular immune response to HCV, such as activating hepatitis C virus (HCV)- specific T cells, including CD4+ and CD8+ T cells. The method can be used in model systems to develop HCV-specific immunogenic compositions, as well as to immunize a mammal against HCV.

L'invention concerne des protéines hybrides de VHC comprenant un domaine de protéase NS3 muté, fusionné au moins à un autre épitope de VHC dérivé d'une autre zone de la polyprotéine de VHC. Les fusions peuvent être utilisées dans des méthodes de stimulation d'une réponse immunitaire cellulaire au VHC, notamment dans l'activation de cellules T spécifiques au virus de l'hépatite C (VHC), comprenant des cellules CD4?+¿ et CD8?+¿. Cette méthode peut être utilisée dans des systèmes modèles pour développer des compositions immunogéniques spécifiques à VHC, ainsi que pour immuniser un mammifère contre le VHC.

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