A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/12 (2006.01) A61K 31/135 (2006.01) A61K 31/137 (2006.01) A61K 31/352 (2006.01) A61K 31/365 (2006.01) A61K 31/395 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/70 (2006.01) A61K 45/06 (2006.01) A61P 25/00 (2006.01) A61P 31/00 (2006.01) A61P 31/10 (2006.01) A61P 35/00 (2006.01) C12Q 1/533 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2481795
The present invention relates to the use of a first agent that attenuates Topoisomerase II (Topo II) activity and a second agent that inhibits Heat Shock Protein 90 (HSP90) for use in chemotherapy. The agents are particularly useful in the treatment of cancer and destruction of micro-organisms. The invention also relates to screening methods, diagnostic methods and methods for evaluating or monitoring chemotherapy regimens.
L'invention concerne l'utilisation d'un premier agent atténuant l'activité de la topoisomérase II (topo II) et d'un second agent inhibant la protéine du stress 90 (HSP90) en vue de leur emploi en chimiothérapie. Ces agents sont particulièrement utilisés pour le traitement du cancer et la destruction de micro-organismes. L'invention concerne également des procédés de sélection, des procédés de diagnostic et des procédés permettant d'évaluer ou de contrôler les schémas chimiothérapiques.
Marks & Clerk
University Of Liverpool
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