Ribozymes having 2'-0 substituted nucleotides in the...

Details Ribozymes having 2'-0 substituted nucleotides in the... Ribozymes having 2'-0 substituted nucleotides in the...

C - Chemistry, Metallurgy

07

H

C07H 21/02 (2006.01) A61K 31/70 (2006.01) C07K 14/16 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2106015

ABSTRACT OF THE DISCLOSURE The present invention provides methods for increasing ribozyme catalytic activity without reducing specificity, which methods comprise contacting an RNA molecule with a ribozyme having a flanking sequence modified to contain 2'- O-substituted nucleotides. The invention also provides ribozymes comprising a flanking sequence modified to contain 2'-O-substituted nucleotides. In addition, the invention provides methods for increasing ribozyme catalytic activity comprising contacting an RNA molecule with a ribozyme having a flanking sequence modified to contain a 2'-O-substituted nucleotide and a facilitator oligonucleotide. The present invention further provides compositions comprising a ribozyme having modified flanking sequences and an effective amount of a facilitator oligonucleotide.

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