Blockade of airway hyperresponsiveness and inflammation in a...

Details Blockade of airway hyperresponsiveness and inflammation in a... Blockade of airway hyperresponsiveness and inflammation in a...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 38/00 (2006.01) A61K 38/08 (2006.01)

Patent

CA 2600765

The physiological role of IGFBP-3 in respiratory inflammation and hyperresponsiveness is presently unknown. The present invention is based on the unexpected finding that both wild-type IGFBP-3 and the IGFBP-3 mutant GGG- IGFBP-3 inhibit tissue inflammation and hyperresponsiveness associated with obstructive respiratory disorders such as bronchial asthma. Provided herein are methods of treating obstructive respiratory disorders and various conditions associated with airway hyperresponsiveness, including asthma, by administering recombinant IGFBP-3 or IGFBP-3 mutants or vectors encoding IGFBP- 3 or IGFBP-3 mutants.

Le rôle physiologique de la protéine IGFBP-3 dans un inflammation et une hypersensibilité respiratoire est aujourd'hui inconnu. Cette invention se fonde sur la découverte inattendue que la protéine IGFBP-3 de type sauvage et la protéine mutante de IGFBP-3 inhibent toutes les deux une inflammation et l'hypersensibilité du tissu associée aux troubles respiratoire obstructifs tels que l'asthme. Cette invention concerne aussi des techniques de traitement des troubles respiratoires obstructifs et de divers états associés à l'hypersensibilité des voies respiratoires, comprenant l'asthme, par l'administration de IGFBP-3 de recombinaison ou de mutants de IGFBP-3 ou de vecteurs codants pour IGFBP-3 ou pour des mutants de IGFBP-3..

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