Extended release formulation

Details Extended release formulation Extended release formulation

A - Human Necessities

61

K

A61K 31/135 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 31/137 (2006.01)

Patent

CA 2305242

This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, and antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. In its primary aspect, this invention provides an improved core of the extended release spheroids comprised of venlafaxine hydrochloride and microcrystalline cellulose, that is, without the addition of hydroxypropylmethylcellulose.

L'invention a pour objet une préparation à libération prolongée avec un dosage agissant sur 24 heures ainsi qu'un dosage sous forme d'unités d'hydrochlorure de venlafaxine, un antidépresseur, qui permet de contrôler le taux de plasma sanguin mieux que les préparations traditionnelles en comprimés, qui doivent être administrées deux fois par jour ou plus souvent; en outre, cette préparation est moins susceptible de provoquer des nausées et des vomissements que les comprimés traditionnels. Dans un premier aspect, l'invention concerne un noyau amélioré constitué de sphéroïdes à libération continue, composés d'hydrochlorure de venlafaxine et de cellulose microcristalline, et ce sans addition de hydroxypropylméthylcellulose.

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