Certain substituted benzylamine derivatives; a new class of...

Details Certain substituted benzylamine derivatives; a new class of... Certain substituted benzylamine derivatives; a new class of...

C - Chemistry, Metallurgy

07

D

C07D 295/096 (2006.01) C07D 213/38 (2006.01) C07D 213/74 (2006.01) C07D 239/42 (2006.01) C07D 241/04 (2006.01) C07D 243/08 (2006.01) C07D 295/033 (2006.01) C07D 309/14 (2006.01) C07D 317/58 (2006.01) C07D 333/36 (2006.01) C07D 335/02 (2006.01) C07D 401/04 (2006.01) C07D 405/02 (2006.01)

Patent

CA 2203878

Disclosed are compounds of the formulas: Image wherein Ar is optimally substituted aryl; B is O, S, NR5 or CR5R6; n is 1, 2 or 3; m is 2,3 or 4; W, X, Y and T are each hydrogen or substituent; R1 and R2 are each hydrogen or alkyl; R3 and R4 are each hydrogen, alkyl or alkoxy; R5 is alkyl or aryl; R6 is hydrogen or substituent; and A is hydrogen or substituent. These compounds bind to neuropeptide Y1 (NPY1) reptor and are useful for treating eating disorders such as obesity and bulimia as well as cardiovascular diseases such as hypertension.

L'invention concerne des composés de la formule (I) ainsi que leurs sels pharmaceutiquement acceptables, formule dans laquelle W, X, Y, A et T représentent des substituants organiques ou inorganiques, n représente 1, 2 ou 3, m représente 2, 3 ou 4, R1-R4 représentent hydrogène ou des substituants organiques, et B représente azote, carbone, soufre ou oxygène. Les composés sont utiles dans le diagnostic et dans le traitement de dérèglements alimentaires tels que l'obésité et la boulimie, et de maladies cardiovasculaires telles que l'hypertension artérielle essentielle et l'insuffisance cardiaque congestive dues à la liaison de ces composés à des récepteurs humains des neuropeptides Y1.

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