C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 407/04 (2006.01) A61K 31/35 (2006.01) A61P 35/00 (2006.01) C07D 493/10 (2006.01)
Patent
CA 2652705
The invention relates to dioxaspiroketal derivatives of formula (I): wherein R, is selected from the group consisting of H, straight or branched chain C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, cycloalkyl, heterocyclyl, phenyl, optionally para-, meta- or ortho-substituted with 0 to 3 substituent selected from halogen, -CN, -NH2, -OH, -NO2, COOR2, wherein R2 is selected from H and C1-C6 alkyl, n is 1 or 2, X is O or S, R1 is selected from H, OH, halogen, C1-C6 alkyl, C1-C6 alkoxy, COOR3, wherein R3 is selected from H and C1-C6 alkyl, or physiologically acceptable salts thereof, process for preparation thereof, their uses in medical field, in particular as anti-tumour medicaments.
L'invention concerne des dérivés de dioxaspirocétal représentés par la formule (I), dans laquelle R est choisi dans le groupe comprenant H, alkyle C1-C6 à chaîne droite ou ramifiée, alcoxy C1-C6, alcényle C2-C6, cycloalkyle, hétérocyclyle, phényle, éventuellement substitué en para, méta ou ortho par 0 à 3 substituants choisis parmi halogène, -CN, -NH2, -OH, -NO2, COOR2, R2 étant choisi parmi H et alkyle C1-C6, n est égal à 1 ou 2, X représente O ou S, R1 est choisi parmi H, OH, halogène, alkyle C1-C6, alcoxy C1-C6, COOR3, R3 étant choisi parmi H et alkyle C1-C6, ou des sels physiologiquement acceptables de ceux-ci. L'invention concerne également un procédé de préparation de ces dérivés, ainsi que leurs utilisations dans le domaine médical, en particulier comme médicaments antitumoraux.
Cottarelli Andrea
de Mico Antonella
Fuggetta Mariapia
Lanzilli Giulia
Tricarico Maria
Consiglio Nazionale Delle Ricerche
Dennison Associates
LandOfFree
Dioxaspiroketal derivatives, process for their preparation... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Dioxaspiroketal derivatives, process for their preparation..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dioxaspiroketal derivatives, process for their preparation... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1587185