A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01)
Patent
CA 2588644
The present invention is directed toward compositions and methods involving the inhibition of li expression in cells for the purpose of altering antigen presentation pathways. More specifically, disclosed are compositions and methods which relate to MHC class II molecule presentation of antigenic epitopes which, under normal circumstances, would not be presented in association with MHC class II molecules. The invention relates to presentation in cells which normally express MHC class II molecules, as well as cells which can be induced to express MHC class II molecules. Embodiments relating to RNA interference of li are specifically disclosed.
L'invention concerne des compositions et des procédés impliquant l'inhibition de l'expression li dans des cellules dans le but d'altérer les voies de présentation d'antigène. L'invention concerne plus particulièrement des compositions et des procédés associés à la présentation de la molécule de classe II MHC d'épitopes antigènes qui, dans des conditions normales, ne seraient pas présentés en association avec les molécules de classe II MHC. L'invention concerne la présentation dans des cellules qui expriment normalement des molécules de classe II MHC, ainsi que des cellules susceptibles d'être induites pour exprimer des molécules de classe II MHC. L'invention concerne des modes de réalisation associés à l'interférence d'ARN de li.
Humphreys Robert
Xu Minzhen
Antigen Express Inc.
Goudreau Gage Dubuc
LandOfFree
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