Stable spray-dried protein formulations

Details Stable spray-dried protein formulations Stable spray-dried protein formulations

A - Human Necessities

61

K

A61K 9/72 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 38/27 (2006.01) A61K 47/24 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2341624

Spray-dried particles having improved protein stability are produced by spray- drying a mixture including a protein, a phospholipid and an organic-aqueous co-solvent. Spray-dried particles which include at least 1 weight % phospholipid, having a tap density of less than 0.4 g/cm3 can be prepared. The particles can be delivered to the pulmonary system of a patient.

La présente invention concerne des particules séchées par atomisation présentant une amélioration de la stabilité des protéines et qui sont produites par atomisation d'un mélange constitué d'une protéine, d'un phospholipide et d'un co-solvant eau/solvant organique. Des particules séchées par atomisation et qui contiennent au moins 1 % en poids de phospholipide présentent une densité après tassement inférieure à 0,4 g/cm<3>. Les particules peuvent être introduites dans le système pulmonaire d'un patient.

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